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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MAP3K5
All Species:
10
Human Site:
S53
Identified Species:
22
UniProt:
Q99683
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q99683
NP_005914.1
1374
154537
S53
L
P
P
P
P
P
G
S
F
W
N
V
E
S
A
Chimpanzee
Pan troglodytes
XP_001171211
1375
154924
S54
L
P
P
P
P
P
G
S
F
W
N
V
E
S
A
Rhesus Macaque
Macaca mulatta
XP_001111127
1297
143635
G38
L
A
A
T
P
G
R
G
C
A
R
S
R
P
L
Dog
Lupus familis
XP_533420
1645
181128
S294
C
L
A
R
R
A
R
S
S
P
E
L
W
L
A
Cat
Felis silvestris
Mouse
Mus musculus
O35099
1380
154441
S60
P
P
P
P
P
P
G
S
F
W
N
V
E
S
A
Rat
Rattus norvegicus
XP_001073260
1338
150427
P39
A
A
P
G
T
S
C
P
T
T
A
P
G
S
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511920
1243
141469
L38
Q
P
S
L
F
Y
H
L
G
V
R
E
S
F
S
Chicken
Gallus gallus
XP_419725
1260
143069
A38
I
A
R
S
F
D
I
A
V
V
E
M
S
D
A
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001155222
1364
153160
S40
S
S
A
G
N
N
S
S
A
G
A
F
W
Q
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_477089
1363
155478
R38
S
A
G
A
N
F
Q
R
V
Q
F
E
R
L
D
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001202919
1288
145042
V39
A
C
R
L
V
N
N
V
T
L
I
K
V
N
F
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.3
44.9
68
N.A.
94.1
92.7
N.A.
84.4
80.4
N.A.
71.7
N.A.
40.6
N.A.
N.A.
44.6
Protein Similarity:
100
99.4
61.3
73.1
N.A.
95.8
94.4
N.A.
87.8
87
N.A.
84.1
N.A.
58.2
N.A.
N.A.
60.7
P-Site Identity:
100
100
13.3
13.3
N.A.
93.3
13.3
N.A.
6.6
6.6
N.A.
6.6
N.A.
0
N.A.
N.A.
0
P-Site Similarity:
100
100
13.3
20
N.A.
93.3
20
N.A.
13.3
26.6
N.A.
6.6
N.A.
0
N.A.
N.A.
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
19
37
28
10
0
10
0
10
10
10
19
0
0
0
46
% A
% Cys:
10
10
0
0
0
0
10
0
10
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
10
0
0
0
0
0
0
0
10
19
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
19
19
28
0
0
% E
% Phe:
0
0
0
0
19
10
0
0
28
0
10
10
0
10
10
% F
% Gly:
0
0
10
19
0
10
28
10
10
10
0
0
10
0
0
% G
% His:
0
0
0
0
0
0
10
0
0
0
0
0
0
0
0
% H
% Ile:
10
0
0
0
0
0
10
0
0
0
10
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
10
0
0
0
% K
% Leu:
28
10
0
19
0
0
0
10
0
10
0
10
0
19
10
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
10
0
0
0
% M
% Asn:
0
0
0
0
19
19
10
0
0
0
28
0
0
10
0
% N
% Pro:
10
37
37
28
37
28
0
10
0
10
0
10
0
10
0
% P
% Gln:
10
0
0
0
0
0
10
0
0
10
0
0
0
10
0
% Q
% Arg:
0
0
19
10
10
0
19
10
0
0
19
0
19
0
0
% R
% Ser:
19
10
10
10
0
10
10
46
10
0
0
10
19
37
19
% S
% Thr:
0
0
0
10
10
0
0
0
19
10
0
0
0
0
0
% T
% Val:
0
0
0
0
10
0
0
10
19
19
0
28
10
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
28
0
0
19
0
0
% W
% Tyr:
0
0
0
0
0
10
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _